What is Age-Related Macular Degeneration (AMD)?

Age-related macular degeneration (AMD) is the most frequent cause of vision loss among people 50 years and older in the Western world.

AMD Symptoms

For instance, some of the symptoms of AMD can include:

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  • Blurry area near center of vision that may increase
  • Blank spots in center of vision
  • Objects not appearing as bright as they used to

Many older people are unaware that they have AMD and may not notice that their vision is deteriorating, particularly if it is only in one eye. Other people may fail to report vision loss because they believe it to be an inevitable consequence of aging. If patients with certain types of AMD are to benefit from recent developments in treatment, an early diagnosis is extremely and equally important. AMD can be classified as either dry or wet.

Dry Age-Related Macular Degeneration

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Dry AMD is the accumulation of drusen, which are small yellow deposits underneath the retina. Dry AMD often does not cause severe vision loss unless central atrophy develops. It is important to monitor patients with dry AMD because it may then progress to wet AMD. The wet form accounts for approximately 90% of severe vision loss in patients with AMD.

Wet Age-Related Macular Degeneration

Wet AMD is the presence of choroidal neovascularization, which is a term that describes abnormal new blood growth underneath the retina. The main symptoms of wet AMD are deterioration in central vision, blind spots, and distorted vision. Definitive diagnosis and classification of choroidal neovascularization requires not only fluorescein angiography, ocular coherence tomography, but also color fundus photography of the retina. The location of neovascular lesions is also an important factor in determining the risk of vision loss. Eyes with subfoveal lesions (those that extend under the center of the retina) are at the greatest risk of vision loss.

Age-Related Macular Degeneration Treatment


At the present time, no intervention has proven to reduce the risk of developing dry AMD and there is no treatment that has shown to reverse the condition.  However, there are ways to manage the progression and improve vision. The Age-Related Eye Disease Study did show that vitamin supplementation can decrease the rate of progression from intermediate to advanced AMD by 25% at 5 years.

Our doctors suggest the following vitamin supplements daily to slow the progression of the visual atrophy from Dry AMD:

  • Vitamin C 500 mg
  • vitamin E 400 IU
  • zinc 80 mg, copper 2 mg
  • lutein 10 mg
  • and zeaxanthin 2 mg
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Generally speaking, one of the most common treatments for wet AMD is the intravitreal administration of medications that block the growth of abnormal blood vessels underneath the retina. They target a specific chemical messenger called Vascular Endothelial Growth Factor (VEGF). Three common medications used in this setting are ranibizumab (Lucentis), aflibercept (Eylea) and bevacizumab (Avastin). Although the intraocular use of Avastin is “off-label,” many patients benefit from this medication. Lucentis, Eylea or Avastin are injected directly into the vitreous cavity in the office. Treatments may be as often as every month, and multiple injections may be necessary in order to keep the condition stable over the long term.

Photodynamic therapy with verteporfin (Visudyne) is another treatment option for wet AMD. With photodynamic therapy, verteporfin is administered by intravenous infusion. A non-thermal laser then treats the target area in the eye. Laser light is applied 15 minutes after the start of the medication infusion. Patients typically receive treatments every 3 months. Patients should avoid exposure to direct sunlight or strong indoor light for 5 days following the procedure.

Another treatment option for wet AMD is the use of a thermal laser, which may be necessary when the abnormal choroidal blood vessels do not extend directly underneath the fovea.

Schedule a Consultation

If you are interested in learning more about Age-Related Macular Degeneration, please call (800) VRS-2500 to schedule a consultation. We have locations in Minneapolis, St. Paul, Blaine, Edina, Oakdale, Plymouth, St. Cloud, and Duluth.